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ID 28861
本文ファイル
著者
Yanase, Yuhki
Uchida, Kazue
Ishii, Kaori
Oomizu, Souichi
Suzuki, Hidenori
Mihara, Shoji
Onishi, Nobukazu
Kameyoshi, Yoshikazu
キーワード
Fucoidan
B cells
T cells
IgE
Ovalbumin (OVA)
NDC
医学
抄録(英)
We previously reported that fucoidan, a dietary fiber purified from seaweed, inhibited IgE production by B cells in vitro. In this study, we examined the effect of fucoidan on IgE production in vivo. The OVA-induced increase of plasma IgE was significantly suppressed when fucoidan was intraperitoneally, but not orally, administered prior to the first immunization with OVA. The production of IL-4 and IFN-gamma in response to OVA in spleen cells isolated from OVA-sensitized mice treated with fucoidan in vivo was lower than that from mice treated without fucoidan. Moreover, the flow cytometric analysis and ELISpot assay revealed that the administration of fucoidan Suppressed a number of IgE-expressing and IgE-secreting B cells, respectively. These results indicate that fucoidan inhibits the increase of plasma IgE through the suppression of IgE-producing B cell population, and the effect of fucoidan in VIVO is Crucially dependent on the route and timing of its administration.
掲載誌名
Biochemical and Biophysical Research Communications
387巻
3号
開始ページ
435
終了ページ
439
出版年月日
2009-09-25
出版者
Academic Press Inc
Elsevier Science
ISSN
0006-291X
NCID
出版者DOI
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
author
権利情報
Copyright (c) 2009 Elsevier Inc.
関連情報URL
部局名
医歯薬学総合研究科