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ID 20782
本文ファイル
著者
Okabe, Tsutomu
Morita, Eishin
Koro, Osamu
Yamamoto, Shoso
キーワード
Ca2+ signal
Leukotriene B4
Mast cell
Mitogen-activated protein kinase
Substance P
NDC
医学
抄録(英)
Substance P (SP) selectively activates mast cells that reside in connective tissues. We studied the reactions of bone marrow-derived mast cells (BMMC) of three mouse strains, cultured with or without fibroblasts. BMMC co-cultured with fibroblasts, but not those cultured alone, increased intracellular Ca2+, released LTB4 and histamine in response to SP. PD098059 significantly inhibited the release of LTB4, but not histamine in all strains. SB203580 failed to reduce or slightly impaired the release of LTB4. These results suggest that mast cells undergo maturation under the influence of fibroblasts, acquiring the responsiveness to SP with Ca2+ signals and predominantly ERK-MAP kinase.
掲載誌名
Journal of Neuroimmunology
181巻
1-2号
開始ページ
1
終了ページ
12
出版年月日
2006-12
出版者
Elsevier B.V.
ISSN
0165-5728
NCID
出版者DOI
PubMedID
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
author
権利情報
Copyright (c) 2006 Elsevier B.V.
関連情報URL(IsVersionOf)
http://dx.doi.org/10.1016/j.jneuroim.2006.07.011
部局名
医歯薬学総合研究科