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ID 34823
本文ファイル
著者
Takatsu, Satomi
Ishiwata, Takayuki
Tanaka, Hideto
Sarre, Sophie
Meeusen, Romain
キーワード
Microdialysis
Exercise
Thermoregulation
Neurotransmission
NDC
生物科学・一般生物学
抄録(英)
The purpose of the present study was to investigate the relationship between thermoregulation and catecholamine release in the preoptic area and anterior hypothalamus (PO/AH) during incremental treadmill running in the rat. To this aim, we combined in vivo brain microdialysis, biotelemetry and metabolic measurements for continuous monitoring of core body temperature (T(core)), neurotransmitters and thermoregulatory responses. The animals were exercised for 1 h at 23 degrees C. Treadmill speed was increased every 20 min (10, 20 and 26 m min(-1)). T(core). oxygen consumption (VO(2), an index of heat production) and tail skin temperature (T(tail), an index of heat loss) were simultaneously measured. Brain microdialysis samples were collected every 10 min, and these samples were analyzed for noradrenaline (NA), dopamine (DA) and serotonin (5-HT). T(core) and VO(2) significantly increased during treadmill and were exercise intensity dependent. After an initial drop T(tail) increased significantly during exercise. Both NA and DA levels in the PO/AH increased significantly during exercise. There was no effect on serotonin release. T(core). VO(2) and T(tail) were positively correlated with the levels of NA and DA. Our data suggest that thermoregulatory responses are dependent on the intensity of the exercise and that these responses are associated with changes in NA and DA release, but not in 5-HT release in the PO/AH.
掲載誌名
Journal of Neuroscience Methods
202巻
2号
開始ページ
119
終了ページ
123
出版年月日
2011
出版者
Elsevier Science BV
ISSN
0165-0270
NCID
出版者DOI
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
author
権利情報
(c) 2011 Elsevier B.V. All rights reserved.
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