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ID 30408
本文ファイル
著者
Abe, Nobukazu
Akiyama, Yuuji
Takaba, Junko
Vishwa, Jeet Amatya
Kajiwara, Yoshinori
Hanaya, Ryosuke
キーワード
Apparent diffusion coefficient
Echo planar imaging
Glioblastoma
Magnetic resonance imaging
Overall survival
NDC
医学
抄録(英)
Purpose: To retrospectively evaluate whether the mean, minimum, and maximum apparent diffusion coefficient (ADC) of glioblastomas obtained from pretreatment MR images is of prognostic value in patients with glioblastoma.

Materials and methods: The institutional review board approved our study and waived the requirement for informed patient consent. Between February 1998 and January 2006, 33 patients (24 males, 9 females; age range 10–76 years) with supratentorial glioblastoma underwent pretreatment magnetic resonance (MR) imaging. The values of the mean, minimum, and maximum ADC (ADCmean, ADCMIN, and ADCMAX, respectively) of each tumor were preoperatively determined from several regions of interest defined in the tumors. After surgical intervention, all patients underwent irradiation and chemotherapy performed according to our hospital protocol. The patient age, symptom duration, Karnofsky performance scale score, extent of surgery, and ADC were assessed using factor analysis of overall survival. Prognostic factors were evaluated using Kaplan–Meier survival curves, the log-rank test, and multiple regression analysis with the Cox proportional hazards model.

Results: Likelihood ratio tests confirmed that ADCMIN was the strongest among the three prognostic factors. Total surgical removal was the most important predictive factor for overall survival (P < 0.01). ADCMIN was also statistically correlated with overall survival (P < 0.05) and could be used to classify patients into different prognostic groups. Interestingly, ADCMIN was also the strongest prognostic factor (P < 0.01) in the group of patients in whom total tumor removal was not possible.

Conclusion: The ADCMIN value obtained from pretreatment MR images is a useful clinical prognostic biomarker in patients with glioblastoma.
掲載誌名
European Journal of Radiology
73巻
3号
開始ページ
532
終了ページ
537
出版年月日
2010-03
出版者
Elsevier Ireland LTD
ISSN
0720-048X
NCID
出版者DOI
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
author
権利情報
Copyright (c) 2009 Elsevier Ireland Ltd
関連情報URL
部局名
医歯薬学総合研究科