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ID 34785
本文ファイル
著者
Motoda, Chikaaki
Ueda, Hironori
Hayashi, Yasuhiko
Toyofuku, Mamoru
Okimoto, Tomokazu
Otsuka, Masaya
Tamekiyo, Hiromichi
Kawase, Tomoharu
キーワード
Anti-platelet therapy
Drug-eluting stent
Percutaneous coronary intervention
Platelet reactivity to ADP
Revascularization
NDC
医学
抄録(英)
Background: Diverse pharmacological effects of anti-platelet thienopyridines due to individual differences in metabolism have been reported. However, an association between on-treatment platelet reactivity and adverse ischemic events after drug-eluting stent (DES) implantation in Japanese patients has not been fully elucidated.

Methods and Results: A total of 450 consecutive patients on dual anti-platelet therapy (aspirin and ticlopidine) with stable angina who underwent DES implantation were enrolled. Adenosine diphosphate (ADP)-induced platelet aggregation was measured before DES implantation using the screen filtration pressure method. The ADP concentration necessary for 50% aggregation was designated as the platelet aggregation threshold index (PATI). A composite primary endpoint of cardiac death, myocardial infarction, target lesion revascularization (TLR), and stent thrombosis occurring within 1 year after stenting, was evaluated. A PATI value <4.8 mu mol/L was defined as high on-treatment reactivity to ADP. The composite primary endpoint occurred in 55 patients (12.2%) in the 1-year-period after DES implantation, and the prevalence was 19.0% and 5.1% in groups with high and low on-treatment reactivity to ADP, respectively, showing a significantly higher prevalence in the high reactivity group (P<0.001). The main event was TLR (18.1% vs. 5.1%, P<0.001).

Conclusions: These data suggested that high on-treatment platelet reactivity to ADP and subsequent occurrence of adverse ischemic events (particularly TLR) were correlated in patients with stable angina who underwent DES implantation. (Circ J 2012; 76: 641-649)
掲載誌名
Circulation Journal
76巻
3号
開始ページ
641
終了ページ
649
出版年月日
2012
出版者
Japanese Circulation Society
ISSN
1346-9843
NCID
出版者DOI
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
権利情報
(c) All rights are reserved to the Japanese Circulation Society.
関連情報URL
部局名
医歯薬学総合研究科