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ID 736
本文ファイル
著者
Shiraki, Katsuhisa
Yano, Raita
Otani, Satoko
Mimeoka, Akane
Watanabe, Hiromitsu
キーワード
Lung tumor inhibition
BHP
Long-term fermented miso
Wistar rats
NDC
医学
抄録(英)
The present study was designed to investigate the effects of fermented miso in the diet on the development of lung tumors initiated by diisopropanolnitrosamine (BHP) in male Slc:Wistar rats. A total of 63 animals, 6 weeks of age, were divided into 4 groups and given BHP (2000 ppm) in their drinking water for 10 weeks. After the carcinogen treatment the rats were fed a normal control MF solid diet, or the same diet containing 100ng-term or short-term fermented miso for 12 weeks. The long-term fermented miso significantly reduced the number of lung tumors, adenocarcinomas and PCNA strongly positive tumors as compared with the short-term fermented miso. The present results thus indicate that dietary supplementation with long-term fermented miso could exert chemopreventive effects on lung carcinogenesis.
掲載誌名
Hiroshima Journal of Medical Sciences
52巻
1号
開始ページ
9
終了ページ
13
出版年月日
2003-03
出版者
Hiroshima University Medical Press
寄与者
国立情報学研究所
作成年月日
2006-03-21
ISSN
0018-2052
NCID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
原爆放射線医科学研究所
医歯薬学総合研究科
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