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ID 45811
本文ファイル
著者
Ikeda, Atsushi 大学院工学研究科 広大研究者総覧
Hino, Shodai
Mae, Tomoya
Tsuchiya, Yuki
Sugikawa, Kouta 大学院工学研究科 広大研究者総覧
Tsukamoto, Manami
Yasuhara, Kazuma
Shigeto, Hajime
Funabashi, Hisakage 大学院先端物質科学研究科 広大研究者総覧
Kuroda, Akio 大学院先端物質科学研究科 広大研究者総覧
Akiyama, Motofusa
NDC
化学
抄録(英)
The water‐solubilisation of porphyrin derivatives is very important for biological applications. Although liposomal drug carriers for porphyrin derivatives have shown significant promise in the field of medicinal chemistry (e.g., as sensitisers for photodynamic therapy), it is currently not possible to prepare lipid‐membrane‐incorporated tetraphenylporphyrin (TPP) with a high concentration of TPP using conventional methods. In this study, we have succeeded in preparing lipid-membrane‐incorporated TPP and zinc(II) tetraphenylporphyrin (ZnTPP) from the corresponding TPP or ZnTPP•cyclodextrin complex using the exchange method in lipid‐membranes composed of liposomes. Furthermore, the exchange method allowed for the incorporation of TPP or ZnTPP into the plasma membranes of HeLa cells. However, it was not possible to prepare lipid‐membrane‐incorporated porphyrin derivatives with polar and hydrophilic groups in the meso positions using this exchange reaction.
内容記述
Electronic supplementary information (ESI) available: Experimental procedures, 1H NMR spectra, DLS measurements, cryo-TEM images, phase contrast and fluorescence images. See DOI: 10.1039/c5ra24985
This work was supported by JSPS KAKENHI a Grant‐in‐Aid for Scientific Research (B) (Grant No. 25288037) and a Grant‐in‐Aid for Young Scientists (A) (Grant No. 24681028).
掲載誌名
RSC Advances
5巻
127号
開始ページ
105279
終了ページ
105287
出版年月日
2015-12-08
出版者
Royal Society of Chemistry
ISSN
2046-2069
出版者DOI
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
権利情報
This journal is © The Royal Society of Chemistry 2015
This is an open access article distributed under the terms of the Creative Commons Attribution 3.0 Unported Licence.
部局名
工学研究科
先端物質科学研究科