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ID 46875
本文ファイル
Thumnail 531.full.pdf 1.74 MB
著者
Miles, Lee B.
Mizoguchi, Takamasa
Kikuchi, Yutaka 大学院理学研究科 広大研究者総覧
Verkade, Heather
キーワード
Endoderm
Planar cell polarity (PCP)
Zebrafish
midline aggregation
Development
NDC
生物科学・一般生物学
抄録(英)
The zebrafish endoderm begins to develop at gastrulation stages as a monolayer of cells. The behaviour of the endoderm during gastrulation stages is well understood. However, knowledge of the morphogenic movements of the endoderm during somitogenesis stages, as it forms a mesenchymal rod, is lacking. Here we characterise endodermal development during somitogenesis stages, and describe the morphogenic movements as the endoderm transitions from a monolayer of cells into a mesenchymal endodermal rod. We demonstrate that, unlike the overlying mesoderm, endodermal cells are not polarised during their migration to the midline at early somitogenesis stages. Specifically, we describe the stage at which endodermal cells begin to leave the monolayer, a process we have termed ‘midline aggregation’. The planar cell polarity (PCP) signalling pathway is known to regulate mesodermal and ectodermal cell convergence towards the dorsal midline. However, a role for PCP signalling in endoderm migration to the midline during somitogenesis stages has not been established. In this report, we investigate the role for PCP signalling in multiple phases of endoderm development during somitogenesis stages. Our data exclude involvement of PCP signalling in endodermal cells as they leave the monolayer.
内容記述
The work was supported by a project grant from the National Health and Medical Research Council (491087) to H.V.
掲載誌名
Biology Open
6巻
開始ページ
531
終了ページ
539
出版年月日
2017-03
出版者
The Company of Biologists Ltd.
ISSN
2046-6390
出版者DOI
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
権利情報
© 2017. Published by The Company of Biologists Ltd., This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
関連情報URL
部局名
理学研究科



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