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ID 48182
file
creator
Shibata, Sachi
Yatagai, Mitsuyoshi
Tateishi, Yoshiko
subject
Chamaecyparis pisifera
Cupressaceae
pisiferic acid
angiogenesis
lymphangiogenesis
endothelial cells
abstract
Pisiferic acid, a diterpene isolated from Chamaecyparis pisifera, has a chemical structure similar to carnosic acid, which has antioxidant activity and exerts various biological effects such as antibiotic and antiangiogenic activity. However, the effect of pisiferic acid on angiogenesis, which is involved in various diseases including cancer and diabetic retinopathy, has not been elucidated. We found that pisiferic acid inhibited angiogenesis and suppressed human umbilical vein endothelial cell tube formation and proliferation but had no effect on human umbilical vein endothelial cell chemotaxis. Furthermore, in lymphangiogenesis assays, pisiferic acid inhibited lymphangiogenesis and lymphatic endothelial cell tube formation and proliferation. Together, these results suggest pisiferic acid to be a useful natural compound, such as carnosic acid, with beneficial effects on angiogenesisand lymphangiogenesis-related diseases.
description
Supporting information available online at http://www.thieme-connect.de/products
This work was supported in part by grants from JSPS KAKENHI, grant numbers 22580130 and 26450159 (K.M.).
journal title
Planta Medica International Open
volume
Volume 3
issue
Issue 02
start page
e31
end page
e34
date of issued
2016-08-22
publisher
Thieme Open
issn
2509‑6656
2199-157X
publisher doi
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
publisher
rights
© Georg Thieme Verlag KG Stuttgart · New York ·
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License.
relation
Planta Med Int Open 2016; 3: e31–e34
relation url
department
Graduate School of Education