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ID 48181
file
creator
Kayashima, Tomoko
Mori, Masaharu
Yoshida, Hiromi
Mizushina, Yoshiyuki
subject
angiogenesis
aortic ring
endothelial cells
vitamin K3
abstract
Vitamins play essential roles in cellular reactions and maintain human health. Recent studies have revealed that some vitamins including D3, B6 and K2 and their derivatives have an anti-cancer effect. As a mechanism, their inhibitory effect on cancer-related angiogenesis has been demonstrated. Vitamin K2 (menaquinones) has an anti-cancer effect in particular for hepatic cancer and inhibits angiogenesis. In the current study, we demonstrated that sole vitamin K3 (menadione) selectively inhibits the in vitro activity of eukaryotic DNA polymerase γ, which is a mitochondrial DNA polymerase, and suppresses angiogenesis in a rat aortic ring model. The anti-angiogenic effect of vitamin K3 has been shown in angiogenesis models using human umbilical vein endothelial cells (HUVECs) with regard to HUVEC growth, tube formation on reconstituted basement membrane and chemotaxis. These results suggest that vitamin K3 may be a potential anti-cancer agent like vitamin K2.
description
This work was supported by the ‘Academic Frontier’ Project for Private Universities (Kobe-Gakuin University), matching fund subsidy from MEXT, 2006-2010, (K.M., H.Y. and Y.M.) and in part by a grant from the Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT). K.M. acknowledges a Grant-in-Aid for Young Scientists (B) (No. 18700608) from MEXT. Y.M. also acknowledges a Grant-in-Aid for Young Scientists (A) (No. 19680031) from MEXT, and Grants-in-Aid from the Nakashima Foundation and the Foundation of Oil & Fat Industry, Kaikan, Japan.
journal title
International Journal of Molecular Medicine
volume
Volume 22
issue
Issue 3
start page
381
end page
387
date of issued
2008-09
publisher
Spandidos Publications
issn
1107-3756
1791-244X
publisher doi
pubmed id
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
publisher
rights
Copyright (c) 2008 Spandidos Publications UK Ltd.
relation
Matsubara, K., Kayashima, T., Mori, M., Yoshida, H., Mizushina, Y. "Inhibitory effects of vitamin K3 on DNA polymerase and angiogenesis". International Journal of Molecular Medicine 22, no. 3 (2008): 381-387.
relation url
department
Graduate School of Education