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ID 47590
file
creator
subject
Aging
Klotho
Renal fibrosis
TGF-β1
Histone methylation
abstract
Systemic symptoms such as the ectopic calcification, atrophy of skin and muscle, and impaired sexual function observed in chronic kidney diseases (CKD) have been reported to coincide with those observed in geriatric symptoms. Regarding the kidney, clinical/pathological characteristics in CKD patients also coincide with those in the aging kidney. These findings suggest common mechanisms in the development of both CKD and aging. Our investigation of aging factors associated with renal fibrosis in IgA nephropathy patients revealed a significant correlation between accumulation of cells with an arrested cell cycle and decreased expression of Klotho protein. Because cell cycle arrest has a protective effect on organs in the acute phase, the proposed therapeutic target against the aging process is to maintain expression of Klotho protein. In addition, it is recognized that TGF-β1 plays a central role in the development of renal fibrosis. However, TGF-β1 has also been reported to decrease expression of Klotho protein. In this report, we provide an interpretation of our new treatment strategy which involves controlling histone methylation.
description
Scientific Aspects of Dialysis Therapy: JSDT/ISBP Anniversary Edition.
This work was supported by the Grant-in-Aid for Scientific Research (KAKENHI) No.16K09610 (to S.D.) in Hiroshima University.
journal title
Contributions to Nephrology
volume
Volume 189
start page
178
end page
183
date of issued
2016-12-12
publisher
S. Karger AG, Basel.
issn
0302-5144
1662-2782
publisher doi
pubmed id
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
author
rights
© 2017 S. Karger AG, Basel.
This is the peer-reviewed but unedited manuscript version of the following article: Contrib Nephrol. 2017;189:178-183. (DOI: 10.1159/000450776). The final, published version is available at http://www.karger.com/?doi=10.1159/000450776
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
relation url
department
University Medical Hospital