ID 33855
file
title alternative
チラミン類縁体N-フェルロイルチラミンによるカエル心室筋内向き整流性カリウムチャンネルに対する影響
creator
Munemori, Makoto
subject
NFT
iK1
Suppression
NDC
Medical sciences
abstract
Electrophysiological effects of N-feruloyl tyramine (NFT), an analogue of tyramine, on potassium currents in frog ventricular myocytes were examined using single-channel recording and whole-cell voltage clamp technique. Extracellular application of NFT induced a concentration-dependent decrease of macroscopic inward rectifier potassium current (iK1) with ID50 of 198 ,#uM, while tyramine (100 #M) was ineffective in producing an inhibitory effect on iK1. NFT reduced the mean open time of iK1 to 1.3 ms from 3.1 ms in control without affecting the amplitude of single-channel conductance. It is indicated that boi containing NFT produces a prolongation of the plateau phase caused by the suppression of inwardly rectifying K channel. Thus, this prolongation may induce an increase in the inflow of Ca ions, which in turn leads to a positive inotropic effect.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 45
issue
Issue 1
start page
31
end page
35
date of issued
1996-03
issn
0018-2052
ncid
SelfDOI
pubmed id
language
eng
nii type
Thesis or Dissertation
HU type
Doctoral Theses
DCMI type
text
format
application/pdf
text version
ETD
rights
Copyright(c) by Author
relation references
Hiroshima J. Med. Sci. Vol.45, No.1, 31-35, March, 1996. HIJM45-5
grantid
甲第1484号
degreeGrantor
広島大学(Hiroshima University)
degreename Ja
博士(医学)
degreename En
Medicine
degreelevel
doctoral
date of granted
1996-03-26
department
Graduate School of Biomedical Science