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ID 45874
file
creator
Teruya, Kiichiro
Myojin-Maekawa, Yuki
Shimamoto, Fumio
Watanabe, Hiromitsu
Nakamichi, Noboru
Tokumaru, Koichiro
Tokumaru, Sennosuke
Shirahata, Sanetaka
subject
Kefir
crypt survival
X-ray
probiotic
reactive oxygen species
mouse
NDC
Medical sciences
abstract
Gastrointestinal damage associated with radiation therapy is currently an inevitable outcome. The protective effect of Kefir was assessed for its usefulness against radiation-induced gastrointestinal damage. A Kefir supernatant was diluted by 2- or 10-fold and administered for 1 week prior to 8 Gray (Gy) X-ray irradiation at a dose rate of 2 Gy/min, with an additional 15 d of administration post-irradiation. The survival rate of control mice with normal drinking water dropped to 70% on days 4 through 9 post-irradiation. On the other hand, 100% of mice in the 10- and 2-fold-diluted Kefir groups survived up to day 9 post-irradiation (p<0.05 and p<0.01, respectively). Examinations for crypt regeneration against 8, 10 and 12 Gy irradiation at a dose rate of 4 Gy/min revealed that the crypt number was significantly increased in the mice administered both diluted Kefir solutions (p<0.01 for each). Histological and immunohistochemical examinations revealed that the diluted Kefir solutions protected the crypts from radiation, and promoted crypt regeneration. In addition, lyophilized Kefir powder was found to significantly recover the testis weights (p<0.05), but had no effects on the body and spleen weights, after 8 Gy irradiation. These findings suggest that Kefir could be a promising candidate as a radiation-protective agent.
journal title
Biological and Pharmaceutical Bulletin
volume
Volume 36
issue
Issue 3
start page
352
end page
359
date of issued
2013-03-01
publisher
The Pharmaceutical Society of Japan
issn
0918-6158
1347-5215
ncid
publisher doi
pubmed id
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
publisher
rights
(c) 2013 The Pharmaceutical Society of Japan
department
Research Institute for Radiation Biology and Medicine