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ID 38364
file
title alternative
ニトロフラントインの経口投与によるマウスでの発癌性について
creator
Ito, Akihiro
Naito, Masashi
Naito, Yukiko
Watanabe, Hiromitsu
subject
Tumorigenicity
N-(5-Nitro-2-furfurylidene)-1-aminohydantoin
Mouse
NDC
Medical sciences
abstract
The carcinogenicity of N-(5-Nitro-2-furfurylidene)-1-aminohydan to in (nitrofurantoin, NF-153) was examined in (C57BL/6N×DBA/2N)F1 (BDF1) mice. Three hundred of mice were divided into three groups, each group consisting about 50 male and 50 female mice. Nitrofurantoin was given in powdered diet at dose levels of 0.3, 0.075, or 0 % to the respestive group of mice. The overall incidence of tumors in male and female mice was as follows: 0.3% NF group, 7.7 and 25.9%; 0.075% NF group, 1.9 and 16.7 %; in the control group, 22.6 and 29.6 %, respectively. In the male, the total incidence of tumors in two experimental groups and that of hepatic adenoma in 0.3% NF group was significantly decreased from that of control by p<0.05 and p<0.05, respectively. There was no significant difference in the female. The results in the present study conclude that nitrofurantoin is not carcinogenic in BDF1 mice.
description
This investigation was supported by a Grant-in-Aid for Cancer Research from the Ministry of Health and Welfare of Japan.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 32
issue
Issue 1
start page
99
end page
102
date of issued
1983-03
publisher
Hiroshima University School of Medicine
issn
0018-2052
ncid
pubmed id
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Research Institute for Radiation Biology and Medicine
Graduate School of Biomedical Science
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