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ID 47050
file
creator
Inoue, Yoshio
Fujimoto, Yasuhiro
Yoshida, Tetsuya
Yamase, Toshihiro
subject
polyoxometalate
human immunodeficiency virus
strain specificity
syncytium formation
cytopathogenicity
NDC
Medical sciences
abstract
The anti-human immunodeficiency virus (HIV) activity of polyoxometalates of representative structural families, such as Keggin, lacunary Keggin, trivacant Keggin, Keggin sandwich, Wells-Dawson and Wells-Dawson sandwich, was determined using two strains of HIV type 1 (HIV-1HTLV-IIIBand HIV-1SF-2H). The compounds were preferably selected to cover both polyoxotungstates and polyoxomolybdates in each structural family. In general, polyoxotungstates of Keggin, lacumary Keggin, trivacant Keggin, Keggin sandwich, Wells-Dawson and Wells-Dawson sandwich structures showed anti-HIV-1HTLV-IIIBactivity, whereas most compounds not included in these structural categories were inactive. Among the compounds with a potent anti-HIV-1HTLV-IIIBactivity, those of Keggin and its closely related structural families (lacunary Keggin, trivacant Keggin and Keggin sandwich) inhibited the cytopathogenicity and syncytium formation caused by HIV-1SF-2Hto a much higher extent compared with HIV-1HTLV-IIIB-related ones. The difference between the spectra of anti-HIV-1HTLV-IIIBactivity and the specificity for HIV-1SF-2Hmight result from differential structural requirements in these functions.
journal title
Biological and Pharmaceutical Bulletin
volume
Volume 18
issue
Issue 7
start page
996
end page
1000
date of issued
1995-07-15
publisher
The Pharmaceutical Society of Japan
issn
0918-6158
1347-5215
ncid
publisher doi
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
publisher
rights
© 1995 Pharmaceutical Society of Japan
relation url
department
Graduate School of Biomedical & Health Sciences