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ID 47064
file
Thumnail 393598.pdf 1.71 MB
creator
Shigemori, Suguru
Oshiro, Kazushi
Wang, Pengfei
Wang, Yeqin
Sato, Takashi
Uyeno, Yutaka
Shimosato, Takeshi
abstract
Previous studies showed that hydrolysates of 𝛽-lactoglobulin (BLG) prepared using gastrointestinal proteases strongly inhibit dipeptidyl peptidase-IV (DPP-IV) activity in vitro. In this study, we developed a BLG-secreting Lactococcus lactis strain as a delivery vehicle and in situ expression system. Interestingly, trypsin-digested recombinant BLG from L. lactis inhibited DPP-IV activity, suggesting that BLG-secreting L. lactis may be useful in the treatment of type 2 diabetes mellitus.
description
The study was supported by a grant from the Iijima Memorial Foundation for the Promotion of Food Science and Technology to Takeshi Shimosato.
journal title
BioMed Research International
volume
Volume 2014
start page
393598
date of issued
2014-08-03
publisher
Hindawi Publishing Corporation
issn
2314-6133
2314-6141
publisher doi
pubmed id
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
publisher
rights
Copyright © 2014 Suguru Shigemori et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
relation url
department
Graduate School of Biosphere Science