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ID 14104
file
creator
Inamatsu, Mutsumi
Tochio, Takumi
Makabe, Aya
Endo, Tetsuya
Oomizu, Souichi
Kobayashi, Eiji
subject
placode
embryonic hairs
hair germs
EGFP-transgenic rats
hair cycle
hair follicles
recombinant skin
skin transplantation
nude mice
NDC
Biology
abstract
Hair induction in the adult glabrous epidermis by the embryonic dermis was compared with that by the adult dermis. Recombinant skin, composed of the adult sole epidermis and the embryonic dermis containing dermal condensations (DC), was transplanted onto the back of nude mice. The epidermis of transplants formed hairs. Histology on the induction process demonstrated the formation of placode-like tissues, indicating that the transplant produces hair follicles through a mechanism similar to that underlying hair follicle development in the embryonic skin. An isolated adult rat sole skin piece, inserted with either an aggregate of cultured dermal papilla (DP) cells or an intact DP between its epidermis and dermis, was similarly transplanted. The transplant produced hair follicles. Histology showed that the epidermis in both cases surrounded the aggregates of DP cells. The epidermis never formed placode-like tissues. Thus, it was concluded that the adult epidermal cells recapitulate the embryonic process of hair follicle development when exposed to DC, whereas they get directly into the anagen of the hair cycle when exposed to DP. The expression pattern of Edar and Shh genes, and P-cadherin protein during the hair follicle development in the two types of transplants supported the above conclusion.
journal title
Development, Growth and Differentiation
volume
Volume 48
issue
Issue 2
start page
73
end page
86
date of issued
2006-02
publisher
Blackwell Publishing
issn
0012-1592
ncid
publisher doi
pubmed id
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
author
rights
Copyright (c) 2006 Blackwell Publishing, Inc
relation is version of URL
http://dx.doi.org/10.1111/j.1440-169X.2006.00848.x
department
Graduate School of Science