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ID 37798
file
creator
Fujii, Satoshi
Kaneko, Mayumi
Inai, Kouki
subject
Replication error (RER)
Loss of heterozygosity (LOH)
Young
Bilateral breast cancer
NDC
Medical sciences
abstract
We examined breast cancers from 67 female patients to ascertain the possible correlation between RER or LOH status, age and bilaterality using eight microsatellite markers on chromosomes 2p, 3p, 16q, 17p and 17q. The frequencies of RER in young patients (25-35 years old), patients with double primary disease (43-77 years old) and patients with contralateral metastases (46-72 years old) were 35%, 63%, and 80%, respectively, while that in elderly patients (60-81 years old) was 0%. In contrast, there were no statistically significant differences in the frequency of LOH between these groups. Our results suggest that RER might play an important role in the occurrence of breast cancer at a younger age and in bilateral breast cancer.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 47
issue
Issue 3
start page
89
end page
97
date of issued
1998-09
publisher
Hiroshima University Medical Press
issn
0018-2052
ncid
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Graduate School of Biomedical Science
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