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ID 34999
file
creator
Iida, Tadayuki
Domoto, Tokio
Takigawa, Atsushi
Nakamura, Satoru
Kato, Yoji
Togo, Masanori
Chikamura, Chiho
Harada, Toshihide
Ishizaki, Fumiko
Ono, Yuichiro
subject
Leptin
Adiponectin
BMD
Women
NDC
Medical sciences
abstract
We conducted a survey of 111 healthy middle-aged and older women, aged 40 to 80 years, to elucidate the relationships between blood leptin and adiponectin levels and bone mineral density (BMD) in September 2008. We examined the associations between the blood levels of these adipocytokines and the lumbar spine (L2-L4), left femoral, and distal forearm BMD after adjustment for the age and body fat percentage. No correlation was observed between leptin and the BMD. This is presumably due to the fact that the influence of menopause, age, duration of postmenopausal period, and body fat percentage on the BMD is greater than that of leptin levels in healthy women. The adiponectin levels were significantly correlated negatively with the lumbar spine and femoral BMD in premenopausal women, and with forearm BMD in postmenopausal women, regardless of adjustment for age and body fat percentage. It seems likely that adiponectin influences the BMD at different skeletal sites in pre- and postmenopausal women.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 60
issue
Issue 4
start page
71
end page
78
date of issued
2011-12
publisher
Hiroshima University Medical Press
issn
0018-2052
ncid
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
rights
(c) Hiroshima University Medical Press.
department
Graduate School of Biomedical Science
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