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ID 37742
file
creator
Isobe, Takeshi
Oguri, Tetsuya
Daga, Haruko
Ishikawa, Hisanobu
Ochiai, Mari
Kitaguchi, Souichi
Ishioka, Shinichi
Yamakido, Michio
subject
Malignant paraganglioma
Posterior mediastinum
p53
ras
NDC
Medical sciences
abstract
An unusual case of paraganglioma of posterior mediastinum occurred in a young adult with local recurrence and multiple distant metastasis. Because of its rarity, the determinants of prognosis factor between benign and malignant paraganglioma are uncertain. In this case, we investigated abnormalities of the p53 gene and ras gene mutations in tissues of primary and metastatic lesions. Neither abnormalities of p53 gene nor ras gene mutations were detected. The molecular approach is recommended as a means of clarifying the trend towards the malignancy of paraganglioma.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 48
issue
Issue 4
start page
123
end page
127
date of issued
1999-12
publisher
Hiroshima University Medical Press
issn
0018-2052
ncid
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Graduate School of Biomedical Science
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