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ID 38033
file
creator
Matsuura, Yuichiro
Matsushima, Takeshi
Mukai, Shogo
Kajihara , Hiroki
subject
Heterotopic cardiac transplantation
Acute cardiac rejection
Endomyocardial biopsy
NDC
Medical sciences
abstract
A model of heterotopic cardiac transplantation for diagnosis of rejection is described. Heterotopic cardiac transplantations were performed in the thorax using the left innominate artery as an arterial supply with venous return into the superior vena cava. Six pairs of mongrel dogs underwent cardiac transplantation using this technique. Two dogs died postoperatively on the 2nd and 3rd day due to respiratory failure. Another four donor hearts arrested their beats in 6 to 8 postoperative days (mean 6.3 days) resulting from acute cardiac rejection. Serial echocardiographic recordings were found to be a reliable measure of acute cardiac rejection, since the left ventricular wall thickness of the donor heart increased until the donor heart stopped by rejection. Endomyocardial biopsy was easy to perform by passage of flexible cardiac biotome into the right ventricle of the donor and the recipient heart through the right internal jugular vein. Pathological findings revealed that early changes of the donor heart were interstitial edema caused by myocardial ischemia. This was followed by lymphocyte infiltration around peripheral coronary arteries and acute rejection resulting in myocyte necrosis.
description
This study was presented in the seventh annual meeting of Japan Cardiac Transplantation Research, May 1989.
Financial contribution was granted by Tsuchiya Memorial Medical Foundation (President Dr. Taro Tsuchiya).
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 39
issue
Issue 1
start page
15
end page
18
date of issued
1990-03
publisher
Hiroshima University Medical Press
issn
0018-2052
ncid
pubmed id
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Graduate School of Biomedical Science
Ohters
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