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ID 27714
file
creator
Tsuda, Hidehiro
Kawaguchi, Hiroyuki
subject
Human pulp cells
interleukin-6
mitogen-activated protein kinases
neodymium-doped yttrium-aluminium-garnet laser
NDC
Medical sciences
abstract
The anti-inflammatory effects of low-power laser irradiation have previously been reported. However, how the laser irradiation regulates the expression of inflammatory cytokines remains unknown. In the present study, to elucidate the mechanism behind the anti-inflammatory effect, we examined the effects of low-power neodymium-doped yttrium-aluminium-garnet (Nd:YAG) laser irradiation on interleukin (IL)-6 expression in human pulp (HP) cells stimulated by peptidoglycan (PGN) and focused on intracellular signaling pathways. Low-power Nd:YAG laser irradiation obviated the PGN-induced increase in IL-6 levels in HP cells. A p38 mitogen-activated protein kinase inhibitor, SB203580, also inhibited the increase in IL-6 messenger RNA levels. PGN stimulated the activity of phosphorylated p38 in HP cells. Low-power laser irradiation inhibited the activity. Thus, suppression of the phosphorylated p38 activity by low-power laser irradiation in HP cells culminates in inhibition of the increase in IL-6 induced by PGN, suggesting that low-power laser irradiation regulates intracellular signaling molecule activities to exert its anti-inflammatory effect. (J Endod 2009;35:373-376)
journal title
Journal of Eenodontics
volume
Volume 35
issue
Issue 3
start page
373
end page
376
date of issued
2009
publisher
Elsevier Science INC
issn
0099-2399
ncid
publisher doi
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
author
rights
Copyright (c) 2009 American Association of Endodontists Published by Elsevier Inc.
relation url
department
Graduate School of Biomedical Science