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ID 46819
file
Thumnail 33_289.pdf 258 KB
creator
Jin, Hekui
Zhao, Xingrong
subject
lactic acid bacterium
intestinal immunity
immunoglobulin A
probiotic
abstract
Some lactic acid bacteria (LAB) are known as representative of probiotics. To screen LAB effective to enhance intestinal immunity, in the present study, we developed an accurate and convenient in vitro evaluation system using Peyer's patch cells (PP-cells) isolated from the mice intestine. We observed that the amount of immunoglobulin A (IgA) produced by PP-cells co-cultured with LAB was well correlative to that in PP-cells, intestine and feces isolated from live mice after oral administration of LAB [correlation coefficient (r)=0.888, 0.883, and 0.920, respectively]. In addition, using this in vitro system, we suggest that the IgA level of PP-cells co-culturing with plant-derived LAB might be more enhanced than with animal-derived LAB.
journal title
Biological and Pharmaceutical Bulletin
volume
Volume 33
issue
Issue 2
start page
289
end page
293
date of issued
2010-02-01
publisher
The Pharmaceutical Society of Japan
issn
1347-5215
0918-6158
ncid
publisher doi
pubmed id
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
publisher
rights
© The Pharmaceutical Society of Japan
relation url
department
Graduate School of Biomedical & Health Sciences