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ID 30399
file
creator
Makihira, Seicho
Shuto, Takahiro
Okamoto, Keishi
Mine, Yuichi
Takamoto, Yuko
Tsuji, Koichiro
subject
antimicrobial peptide
titanium surface
MC3T3-E1 cells
NDC
Medical sciences
abstract
The objective of this study was to evaluate the effect of titanium immobilized with a cationic antimicrobial peptide (JH8194) derived from histatin on the biofilm formation of Porphyromonas gingivalis and differentiation of osteoblastic cells (MC3T3-E1). The titanium specimens (Ti) were immobilized with JH8194, according to the method previously described. The colonization of P. gingivalis on JH8194-Ti was significantly lower than that on control- and blocking-Ti. JH8194-Ti enhanced the mRNA expressions of Runx2 and OPN, and ALPase activity in the MC3T3-E1, as compared with those of control- and blocking-Ti. These results, taken together, suggested the possibility that JH8194-Ti may be a potential aid to shorten the period of acquiring osseointegration.
journal title
International Journal of Molecular Sciences
volume
Volume 11
issue
Issue 4
start page
1458
end page
1470
date of issued
2010-04-02
publisher
Molecular Diversity Preservation International-MDPI
issn
1422-0067
ncid
publisher doi
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
publisher
rights
Copyright (c) 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.
relation url
department
Graduate School of Biomedical Science