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ID 28855
file
creator
Kohyama, Mohei
Takesue, Yoshio
Shimamoto, Fumio
subject
Pouchitis
Pouchitis disease activity index
Ulcerative colitis
NDC
Medical sciences
abstract
To evaluate whether the pouchitis disease activity index (PDAI) alone is sufficient to select appropriate treatment plans for ulcerative colitis patients with bowel movement problems following ileal pouch-anal anastomosis (IPAA). The study included 70 patients undergoing an IPAA. For these patients, an evaluation by PDAI was performed prospectively at 1-2 years after the ileostomy closure. When the symptoms relevant to bowel movement appeared, PDAI was evaluated and metronidazole or ciprofloxacin was administered. Pouchitis was diagnosed in patients with PDAI scores of 7 or higher. The patients whose PDAI score was less than 7 and who responded to antibiotic therapy were defined as treatment responders having disease not diagnosed by PDAI (TR-NDPDAI). Pouchitis was diagnosed in 16 of the 70 enrolled patients (22.9%) using the PDAI scoring system. Of these 16 patients, 11 had acute pouchitis and 5 had chronic pouchitis. Twenty-one patients whose PDAI score was less than 7 were symptomatic. Among them, 12 were TR-NDPDAI. In patients with TR-NDPDAI, antibiotic treatment resulted in significant improvements in the PDAI score (P < 0.001) and in clinical symptoms (P < 0.001) after treatment. Antibiotic treatment was effective in a considerable number of ulcerative colitis patients whose PDAI score was less than 7 after IPAA.
journal title
Surgery Today
volume
Volume 39
issue
Issue 11
start page
962
end page
968
date of issued
2009
publisher
Springer
issn
0941-1291
ncid
publisher doi
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
author
rights
Copyright (c) 2009 Springer
relation
The original publication is available at www.springerlink.com
relation url
department
Graduate School of Biomedical Science