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ID 17683
file
creator
Zhumadilov, Zhaxybay
Hoshi, Masaharu
Takeichi, Nobuo
Abisheva, Gulniaz
Taooka, Yasuyuki
Bhattarcharjee, Deborshi
subject
Fallout Exposure
Late effects
Radiation-induced neoplasm
Therapeutic approaches
NDC
Medical sciences
abstract
It was determined by experts that in the region adjacent to the Semipalatinsk Nuclear Test Site thyroid nodular prevalence was significantly associated with radiation dose from nuclear weapons testing. The medical rehabilitation of patients is of special practical and scientific importance in this region. Some patients have contraindications for surgery and radioiodine or refuse them for various reasons. Percutaneous intranodular injection therapy by "Paoscle" (PIITP) was used for treatment of patients with benign thyroid nodular diseases. The study group included a total of 107 patients (mainly "pretoxic" and "compensated" nodules). Seventyfour patients received PIITP on an out-patient basis. Seventy-two of them were women and 2 men, mean age, 52.9±1.3 years; range 26 to 77 years. Thyroid ultrasound examination, fineneedle aspiration biopsy, thyroid function tests and cytopathology were performed in all patients to evaluate the effectiveness of treatment. The nodule volume reduction rate for patients with thyroid adenomas was 56% on average and 60.2% in the case of colloid nodules. The reduction rate of thyroid adenomas with necrotic and cystic degeneration was higher and reached 72%. The suggested method is indicated for cases of benign nodular thyroid diseases (cysts, adenomas, adenomas with necrotic and cystic degeneration, colloid nodules, polynodular goiter). We did not reveal any complications or thyroid test abnormalities after the treatment. A tendency to normalization of the blood serum thyroglobulin level and antibodies to thyroglobulin was documented. Analysis of the treatment results revealed that this approach is effective, inexpensive, safe, well tolerated and can be used on an outpatient basis.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 52
issue
Issue 4
start page
81
end page
89
date of issued
2003-12
publisher
Hiroshima University Medical Press
国立情報学研究所
issn
0018-2052
ncid
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Research Institute for Radiation Biology and Medicine
Graduate School of Biomedical Science
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