Incorporation of large guest molecules into liposomes via chemical reactions in lipid membranes
OBC_15-8_1786.pdf 1.86 MB
The incorporation of hydrophobic guest molecules into lipid membranes by the exchange of the guest molecule from a cyclodextrin (CDx) complex to a liposome is limited to guest molecules that can be included in CDxs. To solve this problem, large guest molecules were incorporated into liposomes by chemical reactions of guest molecules in lipid membranes. Stable lipid-membrane-incorporated fullerene derivatives with large substituent(s) were prepared by Diels–Alder reactions in lipid membranes.
Electronic supplementary information (ESI) available: Schematic representation of the premixing and exchange methods, 1H NMR spectra and UV-vis absorption spectra. See DOI: 10.1039/c6ob02343f
This work was supported by the Japanese Society for the Promotion of Science (JSPS) KAKENHI Grant-in-Aid for Scientific Research (B) (Grant No. JP16H04133) and a Grant-in-Aid for Challenging Exploratory Research (Grant No. JP16K13982).
Organic and Biomolecular Chemistry
|date of issued||
Royal Society of Chemistry
Copyright (c) 2017 The Royal Society of Chemistry
This is an open access article distributed under the terms of the Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0)
Graduate School of Engineering