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ID 46202
file
creator
Funada, Rikushi
NDC
Chemistry
abstract
Liposomes composed of unsaturated lipids were more stable than those containing saturated lipids toward DMe‐β‐CDx, DMe‐α‐CDx and DMe‐β‐CDx. The Hill coefficient values (n) indicated that the saturated lipid•DMe‐CDx complexes had stoichiometric ratios in the range of 1:3‒1:4, while the unsaturated lipid•DMe‐CDx complexes had ratios in the range of 1:1.5‒1:3. That is, a cis alkene group in the unsaturated lipids prevented complexation with a second DMe‐CDx in the direction toward each acyl chain. Furthermore, the liposomes composed of the unsaturated lipids were much slower to form precipitates upon the addition of α‐CDx than those of the saturated lipids. To the best of our knowledge, this is the first example showing that CDxs interact with unsaturated lipids.
description
This work was supported by the Japanese Society for the Promotion of Science (JSPS) KAKENHI a Grant‐in‐Aid for Scientific Research (B) (Grant No. 25288037 and No. 16H04133) and a Grant‐in‐Aid for Challenging Exploratory Research (Grant No. 16K13982).
journal title
Organic and Biomolecular Chemistry
volume
Volume 14
issue
Issue 22
start page
5065
end page
5072
date of issued
2016-06-04
publisher
Royal Society of Chemistry
issn
1477-0520
publisher doi
pubmed id
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
author
rights
Copyright (c) 2016 The Royal Society of Chemistry
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
department
Graduate School of Engineering