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ID 25913
file
creator
Kume, Ayaka
Okuma, Yasunobu
Nomura, Yasuyuki
subject
endoplasmic reticulum stress
vanadate; glucose-regulated protein 78 (GRP78)
CCAAT/enhancer-binding protein homologous protein (CHOP)
NDC
Medical sciences
abstract
The disruption of endoplasmic reticulum function leads to an accumulation of unfolded proteins, which results in endoplasmic reticulum stress. In the present study, we investigated the effect of vanadate on such stress. Endoplasmic reticulum stress increased glucose-regulated protein 78 (GRP78) and CCAAT/enhancer-binding protein homologous protein (CHOP) expressions in glial cell cultures. We found that vanadate inhibited the endoplasmic reticulum stress-induced increase in GRP78 and CHOP expressions at both mRNA and protein levels. Thus, these results suggest that vanadate modulates endoplasmic reticulum stress responses and that novel vanadate-responsive protein(s) might be involved in these processes.
journal title
European Journal of Pharmacology
volume
Volume 594
issue
Issue 1-3
start page
44
end page
48
date of issued
2008-10-10
publisher
Elsevier Science BV
issn
0014-2999
ncid
publisher doi
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
author
rights
Crown Copyright (c) 2008 Published by Elsevier B.V. All rights reserved.
relation url
department
Graduate School of Biomedical Science