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ID 17065
file
creator
Hyoda, Kanae
Okuma, Yasunobu
Nomura, Yasuyuki
subject
4-(2-aminoethyl)-benzenesulfonyl fluoride (AEBSF)
phosphatidylinositol 3-kinase (PI3K)
CHOP
endoplasmic reticulum stress
NDC
Medical sciences
abstract
Endoplasmic reticulum stress contributes to several diseases such as neurodegenerative disorders and diabetes. In the previous report, we found that phosphatidylinositol 3-kinase (PI3K) down-regulation is important for inducing CHOP expression, an endoplasmic reticulum stress-induced transcription factor. In the present study, we investigated the effect of 4-(2-aminoethyl)-benzenesulfonyl fluoride (AEBSF), a serine protease inhibitor, on PI3K inhibitor-induced CHOP expression. We found that AEBSF completely inhibited PI3K inhibitor-induced CHOP expression at both mRNA and protein levels. It is suggested that AEBSF is an important drug from a pharmacological point of view and the results may have important implications for understanding endoplasmic reticulum stress-related diseases.
journal title
European Journal of Pharmacology
volume
Volume 554
issue
Issue 1
start page
8
end page
11
date of issued
2007-01-05
publisher
Elsevier
issn
0014-2999
ncid
publisher doi
pubmed id
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
author
rights
Copyright (c) 2007 Elsevier Ltd.
relation is version of URL
http://dx.doi.org/10.1016/j.ejphar.2006.09.063
department
Graduate School of Biomedical Science