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ID 26280
file
title alternative
The role of lactic acid in muscle contraction
creator
Mishima, Takaaki
Yamada, Takashi
subject
lactate
lactic acidosis
temperature, pH
筋疲労
筋収縮
運動
カルシウム
NDC
Sports and physical training
abstract
Repeated intense skeletal muscle contraction leads to a progressive loss of force-generating capacity. This decline in function is generally referred to as muscular fatigue. Since the work of Fletcher and Hopkins (1907), it has been known that fatigued muscles accumulate lactic acid. Intracellular acidosis due to lactic acid accumulation has been regarded as the most important cause of fatigue during intense exercise. Recent challenges to the traditional view, however, have suggested that lactic acid plays a role in muscle contraction distinct from that implied by earlier studies. This brief review presents (1) a short history of our understanding about lactic acid that explains the early acceptance of a causal relationship between lactic acid and fatigue, (2) evidence to show the temperature dependence of acidosis-induced changes and the beneficial effect of acidosis, and (3) a proposal that lactate production retards, not causes, acidosis. These findings require us to reevaluate our notions of lactic acid, acidosis and muscular fatigue.
description
Japan J. Phys. Educ. Hlth. Sport Sci. 51: 229239, May, 2006
journal title
体育學研究
volume
Volume 51
issue
Issue 3
start page
229
end page
239
date of issued
2006-05-10
publisher
日本体育学会
issn
0484-6710
ncid
language
jpn
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
publisher
rights
Copyright (c) 2006 日本体育学会
この論文の著作権は(社)日本体育学会に帰属します
department
Graduate School of Integrated Arts and Sciences