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ID 26278
file
title alternative
Structure of sarcoplasmic reticulum and activity-induced alteration in its function
creator
Inashima, Shuichiro
Yasuda, Toshihiro
Matsunaga, Satoshi
subject
muscular fatigue
muscle contraction
exercise
calcium
筋疲労
筋収縮
運動
カルシウム
NDC
Sports and physical training
abstract
Repeated contractions of skeletal muscle lead to a decline of force known as fatigue. The exact cause of muscular fatigue probably involves numerous factors which influence force production in a manner dependent on muscle fiber type and activation pattern. However, a growing amount of evidence implicates alteration of intracellular Ca2+ handling as a major contributor to fatigue. These changes are known to occur secondary to reductions in the rates of Ca2+ uptake and release by the sarcoplasmic reticulum (SR). In this brief review, we focus on two major aspects: 1) molecular mechanisms of the Ca2+ uptake and release process, focusing on Ca2+-ATPase protein and the ryanodine receptor; and 2) several factors that may be responsible for dysfunction of the SR resulting from contractile activity. Factors that might account for diminished function of the SR include a fall in internal pH, increased Ca2+ concentration, modification by reactive oxygen species, depletion of high-energy phosphate, and accumulation of inorganic phosphate.
description
Japan J. Phys. Educ. Hlth. Sport Sci. 46 : 443-459, September, 2001
journal title
体育學研究
volume
Volume 46
issue
Issue 5
start page
443
end page
459
date of issued
2001-09-10
publisher
日本体育学会
issn
0484-6710
ncid
language
jpn
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
publisher
rights
Copyright (c) 2001 日本体育学会
この論文の著作権は(社)日本体育学会に帰属します
department
Graduate School of Integrated Arts and Sciences