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ID 25996
file
title alternative
EFFECTS OF EXHAUSTIVE EXERCISE ON SARCOPLASMIC RETICULUM ATPase : COMPARISON OF SHORT- AND LONG-TERM EXERCISE
creator
Inashima, Shuichiro
Yasuda, Toshihiro
Inamizu, Atsushi
Katsuta, Shigeru
subject
muscle fatigue
skeletal muscle
Ca^<2+>-ATPase
sarcoplasmic reticulum
exercise
NDC
Medical sciences
abstract
Effects of short-term, high-intensity and long-term, moderate-intensity exercise on biochemically assessed asrcoplasmic reticulum(SR)ATPase protein were analyzed in muscle homogenates of the rat after treadmill runs to exhaustion(avg.time to exhaustion 2min 48sec and 1h 29min, respectively). The exercise-induced changes in SR Ca^<2+>-ATPase activity were muscle type-specific. After short-term exercise, a decrease in the activity occurred in the soleus muscle and the super-ficial region of the vastus lateralis muscle whereas long-term exercise depressed the rate of ATP hydrolysis in the soleus muscle and the deep region of the vastus lateralis muscle. The concentration of fluorescein isothiocyanate, a competitor at the ATP-binding site, for 50% inhibition of SR Ca^<2+>-ATPase activity fluctuated only in the soleus muscle subjected to short-term exercise;it was increased by 31%. This change occurring in the soleus muscle would elevate SR Ca^<2+>-ATPase activity at a given concentration of ATP. The results presented here suggest that acute short-term exercise to exhaustion may exert a remarkably inhibitory factor on SR Ca^<2+>-ATPase protein of slow-twitch muscle, which can overcome the positive effect probably arising from the phosphorylation of the phospholamban.
journal title
体力科学 : Japanese Journal of Physical Fitness and Sports Medicine
volume
Volume 47
issue
Issue 1
start page
63
end page
71
date of issued
1998-02-01
publisher
日本体力医学会
issn
0039-906X
ncid
language
jpn
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
publisher
rights
日本体力医学会
本文データは学協会の許諾に基づきCiNiiから複製したものである
relation url
department
Graduate School of Integrated Arts and Sciences