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ID 35023
file
creator
Jitsuiki, Hiroaki
Izumitani, Satoru
Suzuki, Katsuji
Tanaka, Teruaki
Inoue, Takeshi
Koyama, Tsukasa
Wada, Ken
Masaoka, Yukari
Sasaki, Takanobu
Yoshimura, Reiji
Nakamura, Jun
Sumitani, Satsuki
Ohmori, Tetsuro
subject
Valproate
Serum valproate level
Bipolar disorder
Maintenance therapy
NDC
Medical sciences
abstract
The appropriate therapeutic serum valproate level in maintenance therapy for bipolar disorder is not well known. We studied the serum valproate levels in seventeen bipolar I and twenty-four bipolar II disorder outpatients who had been treated with stable doses of valproate successfully for at least 12 months as prophylactic therapy. The trough serum valproate levels were 52.2 ± 20.4 μg/ml in bipolar I, and 41.0 ± 18.3 μg/ml in bipolar II disorder patients, respectively. A greater trend towards a higher trough level (p=0.07) was indicated in the bipolar I disorder group. We speculate that these valproate levels may be an approximation to the appropriate valproate levels in maintenance therapy and that there may be a correlation between the level of valproate required for stabilization and the subtype of the bipolar disorder. However, when interpreting these findings, certain limitations to this study?need to be taken into account as follows. The sample size was small. We could not look at a group on valproate that had relapsed and a group that had dropped out of maintenance therapy. Further studies are needed.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 62
issue
Issue 1
start page
7
end page
12
date of issued
2013-03
publisher
Hiroshima University Medical Press
issn
0018-2052
ncid
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
rights
(c) Hiroshima University Medical Press.
department
Graduate School of Biomedical & Health Sciences
University Medical Hospital
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