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ID 30414
file
creator
Fujikawa, Tokumi
Takami, Hiroshi
Yanai, Ichiro
Morinobu, Shigeru
subject
elderly
major depression
silent cerebral infarction
magnetic resonance imaging
prognosis
dementia
NDC
Medical sciences
abstract
.
abstract
OBJECTIVE: Many studies have examined the effects of cerebrovascular change on treatment response in geriatric depression. However, few such studies have examined the relationship between cerebrovascular changes and long term prognosis. We examined the effects of cerebrovascular change on the course of geriatric depressive symptoms, dementia rates, and mortality over a follow-up period of approximately 10 years.

METHOD: Participants were 84 patients with major depression (age of onset greater than 50 years old); patients suffering from strokes, neurological disorders, and other psychiatric disorders were excluded. MRI findings were used to classify all patients into silent cerebral infarction (SCI) positive (n = 37) or negative groups (n = 47). Patient prognoses were ascertained using a review of clinical charts and over the mail.

RESULTS: Only 5% of patients with SCI were able to maintain remission, whereas 36% of those patients without SCI were able to do so. Total duration of depressive episodes was significantly longer in the SCI positive group than in the SCI negative group. In addition, SCI was associated with a higher risk of the onset of dementia.

CONCLUSION: The results of this long-term follow-up study demonstrate that the presence of SCI is associated with a relatively poor prognosis for geriatric depression
journal title
Neuropsychobiology
volume
Volume 62
issue
Issue 3
start page
177
end page
181
date of issued
2010
publisher
Karger
issn
0302-282X
ncid
publisher doi
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
author
rights
Copyright (c) 2010 S. Karger AG, Basel
relation url
department
Graduate School of Biomedical Science