このエントリーをはてなブックマークに追加
ID 37709
file
creator
Ishioka, Shinichi
Hozawa, Soichiro
Maeda, Akihiro
Tamagawa, Kotaro
Watanabe, Tetsuya
Hiyama, Keiko
Yamakido, Michio
subject
Pranlukast
Cysteinyl leukotriene
Bronchial responsiveness
Aspirin-intolerant asthma
NDC
Medical sciences
abstract
Cysteinyl leukotrienes (cysLTs) are considered to be the most important mediator involved in the pathogenesis of aspirin-intolerant asthma (AIA). However, the role of cysLTs in the baseline condition of the pathophysiology of AIA when not exposed to non-steroidal antiinflammatory drugs (NSAIDs) as well as that in the pathophysiology of aspirin-tolerant asthma remains to be elucidated. Therefore, we evaluated the effect of pranlukast, a potent, selective cysLT receptor antagonist, on bronchial responsiveness to methacholine, a non-specific stimulus, in 7 well-controlled aspirin-intolerant asthmatics receiving oral or inhaled corticosteroid treatment. Pranlukast was orally administered at a dose of 225 mg twice daily to all patients for 4 weeks, and the methacholine challenge test was performed before and after pranlukast treatment. The methacholine provocative concentration producing a 20% fall in forced expiratory volume in 1 second (PC₂₀-FEV₁) was calculated as an index of bronchial hyperresponsiveness (BHR). The geometric mean values of PC₂₀-FEV₁ significantly (p = 0.028) increased from 0.34 mg/dl to 0.61 mg/dl after pranlukast treatment. No significant differences were observed in the baseline values of forced vital capacity (FVC) or FEV1 before and after pranlukast treatment. These findings suggest that antagonism of endogenous cysLT by pranlukast may be responsible for the improvement of BHR to methacholine.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 49
issue
Issue 2
start page
105
end page
108
date of issued
2000-06
publisher
Hiroshima University Medical Press
issn
0018-2052
ncid
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Graduate School of Biomedical Science
他の一覧