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ID 25899
file
title alternative
Therapeutic Effects of Antimicrobial Compounds against Bacillary Necrosis of Larval Pacific Oyster
creator
Matsubara, Danji
Tanaka, Makoto
Soumyou, Yoshie
Hirakawa, Kohji
Doi, Ryuji
subject
Crassostrea gigas
chemotherapy
bacillary necrosis
Vibrio splendidus
Pacific oyster
NDC
Fishing industry. Fisheries
abstract
三倍体マガキ幼生の細菌性壊死症に有効な薬剤の検索を目的として、人為感染および自然感染に対する8種抗菌剤の治療効果を調べた。Vibrio属細菌4種7株を用いた人為感染に対しては、クロラムフェニコールの効果が最も高く、エリスロマイシン, ノボビオシン, ストレプトマイシンなどにも顕著な治療効果が認められた。自然感染に対しては、幼生を高密度飼育した場合クロラムフェニコール添加区の死亡率が最も低かったが、低密度飼育では上記4種薬剤は同程度の防除効果を示した。
abstract
Eight antimicrobial compounds were examined to evaluate their therapeutic effects against experimentally or naturally induced vibriosis of the Pacific oyster Crassostrea gigas. In experimental infections with a strain of Vibrio splendidus biovar II, a causative agent of bacillary necrosis of cultured triploid oyster larvae, chloramphenicol (CP) exhibited complete protection against challenges at 10^5 or 10^6 CFU/mL, and erythromycin (EM), novobiocin (NB), gentamicin and streptomycin (SM) were effective to reduce the mortality, but nalidixic acid or oxytetracycline was not. CP and EM were also highly effective against experimental infections with other six strains of Vibrio species (V. splendidus biovar II, V. pelagius I, V. campbellii, and V. tubiashii) which had been isolated from oyster larvae or the rearing water, but NB and SM were less effective. On the other hand, not only CP and EM but also NB and SM exhibited higher protection against the natural infection.
journal title
Fish Pathology
volume
Volume 37
issue
Issue 4
start page
183
end page
188
date of issued
2002-12
publisher
日本魚病学会
issn
0388-788X
ncid
language
jpn
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
publisher
rights
Copyright (c) 2002 The Japanese Society of Fish Pathology
department
Graduate School of Biosphere Science