このエントリーをはてなブックマークに追加
ID 27757
file
creator
Ohashi, Norihiko
Ito, Chikako
Fujikawa, Rumi
subject
visceral adipose tissue (VAT)
high-molecular weight (HMW) adiponectin
metabolic syndrome (MetS)
cardio-ankle vascular index (CAVI)
arterial stiffness
NDC
Medical sciences
abstract
Few studies addressed the relation of visceral adiposity and high-molecular weight (HMW) adiponectin to arterial stiffness. We investigated the impact of visceral adipose tissue (VAT) and HMW adiponectin on cardio-ankle vascular index (CAVI) in asymptomatic Japanese subjects. We studied 487 consecutive subjects (271 men and 216 women) who underwent general health examination between October 2005 and May 2008. The abdominal, visceral, and subcutaneous adipose tissue areas were determined by low-dose x-ray computed tomography. Serum levels of total and HMW adiponectin were measured using the enzyme-linked immunosorbent assay system based on a monoclonal antibody to humans. Cardio-ankle vascular index was positively correlated with VAT area and negatively correlated with HMW adiponectin levels. We also found the positive association of the number of metabolic syndrome components with CAVI in both sexes. A stepwise multiple regression analysis revealed that age, VAT area, serum HMW adiponectin levels, and homeostasis model assessment of insulin resistance were independent determinants of CAVI. Receiver operating characteristic analyses demonstrated that the predictive value of the VAT area for the extent of CAVI (mild: <25th percentile vs severe: >75th percentile) exceeded that of total or HMW adiponectin levels in both sexes. In conclusion, increased CAVI is associated with both amounts of VAT measured by computed tomography and serum HMW adiponectin levels in asymptomatic Japanese subjects. Receiver operating characteristic analysis indicates that the VAT area is a lot better predictor of arterial stiffness than adiponectin levels.
journal title
Metabolism-Clinical and Experimental
volume
Volume 58
issue
Issue 7
start page
1023
end page
1029
date of issued
2009
publisher
W B Saunders CO-Eleevier Inc
issn
0026-0495
ncid
publisher doi
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
author
rights
Copyright (c) 2009 Elsevier Inc.
relation url
department
Graduate School of Biomedical Science