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ID 45401
file
creator
Nomura, Toshihito
Yoshimoto, Reiko
Kawabata, Ryoko
Matsubara, Toshiki
Narai, Seika
Oda, Kosuke
subject
anti-viral reagents
cytotoxicity
influenza virus
feline calicivirus
NDC
Medical sciences
abstract
Manda Koso is a commercial fermented plant product (FPP) made from 53 types of fruits and vegetables that are fermented for more than 3 years. We hypothesized that the FPP can prevent infection by influenza virus and human norovirus. Therefore, we investigated the effects of the FPP on influenza virus and feline calicivirus, a surrogate of human norovirus. We found that 10% FPP inactivated the influenza virus but not the feline calicivirus. Inhibition of the influenza virus was highly concentration-dependent: 1% and 0.3% FPP showed reduced inactivation efficacy. The effects of the FPP on the influenza virus-infected cells were investigated by addition of the FPP to the culture medium after virus infection. No suppressive effect of the FPP on influenza replication in MDCK cells was observed. The results showed that the FPP could inactivate influenza virus by affecting the virus particles.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 66
issue
Issue 4
start page
97
end page
101
date of issued
2017-12
publisher
Hiroshima University Medical Press
issn
0018-2052
ncid
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
rights
Copyright (c) 2017 Hiroshima University Medical Press
department
Graduate School of Biomedical & Health Sciences
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