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ID 39059
file
creator
Nakanuno, Ryuichi
Yoshikawa, Hiroshi
subject
Inflammatory response
Propofol
Sevoflurane
Midazolam
NDC
Medical sciences
abstract
Responses to surgical stress can be modulated by anesthetics. We prospectively compared the effects of two different anesthetic/sedative techniques on the peak postoperative bladder temperature (BT) and the postoperative C-reactive protein (CRP) level. Twenty patients who were scheduled to undergo elective thoracoabdominal esophagectomy were allocated to receive either propofol anesthesia followed by propofol sedation (PP group, n = 10) or sevoflurane anesthesia followed by midazolam sedation (SM group, n = 10). In each case, the patient’s peak bladder temperature was measured on the morning after surgery, and their serum CRP levels were assessed on postoperative days (POD) 1, 2, and 3. The patients’ postoperative clinical courses were also evaluated. The peak postoperative BT (°C) (37.6 ± 0.4 vs. 38.2 ± 0.6, respectively; p <0.05) and the CRP level on POD 2 (mg/dl) (14.3 ± 3.9 vs. 20.6 ± 3.9, respectively; p <0.05) were lower in the PP group than in the SM group. The peak postoperative BT was positively correlated with the CRP level on POD 2 (R = 0.533, p < 0.05). There were no significant differences between the clinical course-related parameters in both groups. Proposal anesthesia and postoperative propofol sedation resulted in a reduced peak postoperative BT and lower CRP levels on POD 2 after esophagectomy than sevoflurane anesthesia followed by midazolam sedation.
description
This study was supported by the Hiroshima University Support Foundation.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 64
issue
Issue 3
start page
31
end page
37
date of issued
2015-09
publisher
Hiroshima University Medical Press
issn
0018-2052
ncid
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
rights
Hiroshima University Medical Press
department
University Medical Hospital
Graduate School of Biomedical & Health Sciences
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