このエントリーをはてなブックマークに追加
ID 38323
file
title alternative
Wistar/Furth 亜系ラットに認められた盲腸部異型上皮について
creator
Naito, Masashi
Naito, Yukiko
Watanabe, Hiromitsu
Ito, Akihiro
subject
Caecal dysplasia
Spontaneous colon tumor
Rats
NDC
Medical sciences
abstract
Offspring of spontaneous colon tumor prone rats (WF/O) bred in our laboratory developed tumors in a very low incidence (less than 0.2 %), but about half of these rats had dysplastic epithelium with frequent erosion in the caecum. In nine animals (4.4%) submucosal glands of the caecum were observed. These dysplasia accompanied inflammatory cell reactions and regional lymph nodes were enlarged and packed with many plasma cells. Hybrid of WF/O rats and other inbred Long-Evans strain (LE) rats, having no dysplastic lesion of the caecum, had caecal dysplasia in a low incidence (10%). These data suggest that genetic factor(s) play an important role in the occurrence of caecal dysplasia in WF/O rats. These changes may be a precondition to the spontaneous occurrence of tumors in the proximal portion of the ascending colon with the aid of promoting factor(s).
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 32
issue
Issue 3
start page
295
end page
299
date of issued
1983-09
publisher
Hiroshima University School of Medicine
issn
0018-2052
ncid
pubmed id
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Research Institute for Radiation Biology and Medicine
Graduate School of Biomedical Science
他の一覧



Last 12 months's access : ? times
Last 12 months's DL: ? times


This month's access: ? times
This month's DL: ? times