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ID 25938
file
creator
Tanimoto, Keiji
Nishimura, Youhei
Tsugane, Momomi
Fukuba, Ikuko
Nishiyama, Masahiko
subject
lung fibroblast
microarray
growth regulation
proliferation
telomerase
NDC
Medical sciences
abstract
Regulation mechanism of lung fibroblast proliferation remains unknown. To elucidate the key molecules in it, we here established mortal and immortal non-transformed lung fibroblast cell line/strains with elongated lifespan by telomerase reversetranscriptase gene transfection. Comparing the expression profiles of them, 51 genes were explored to be the candidates responsible for regulation of cellular proliferation of lung fibroblasts. This set of fibrobrast strains of same origin with different proliferative capacities may become useful model cells for research on lung fibroblast growth regulation and the candidate genes explored in this study may provide biomarkers or therapeutic targets of pulmonary fibrosis.
journal title
Experimental Lung Research
volume
Volume 34
issue
Issue 7
start page
373
end page
390
date of issued
2008-09
publisher
Taylor & Francis Inc
issn
0190-2148
ncid
publisher doi
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
author
rights
Copyright (c) 2008 Taylor & Francis
relation
This is a preprint of an article submitted for consideration in the Experimental Lung Research © 2008 copyright Taylor & Francis; Experimental Lung Research is available online at informaworldTM with the open URL of your article;
relation url
department
Research Institute for Radiation Biology and Medicine
Graduate School of Biomedical Science



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