Antitumor Effects of Natural-Human TNF on BDFI Mice Bearing Lewis Lung Carcinoma
Hiroshima Journal of Medical Sciences Volume 36 Issue 1
Page 105-111
published_at 1987-03
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| File | |
| Title ( eng ) |
Antitumor Effects of Natural-Human TNF on BDFI Mice Bearing Lewis Lung Carcinoma
|
| Creator |
ITANO Satoshi
FUCHIMOTO Sadanori
ORITA Kunzo
|
| Source Title |
Hiroshima Journal of Medical Sciences
|
| Volume | 36 |
| Issue | 1 |
| Start Page | 105 |
| End Page | 111 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| Abstract |
Natural-human tumor necrosis factor (n-TNF) was obtained by isolating and refining lymphokines which were extracted from human acute lymphoblastic leukemia BALL-I cells. Antitumor effects of this n-TNF were studied by using Lewis lung carcinoma (3LL) which was transplanted on BDFI mice.
n-TNF showed inhibitory effects of the proliferation of metastatic tumors dose-dependently through i.v. injection daily for 10 days. And the study of the dose schedule of the administration and the route of the administration showed that routes of i.v., i.m. and i.t. injections were effective respectively through daily administration. Histological study showed effects which were ranked Grade Ilb (and partially III) of Shimosato and Ohboshi's histological criteria. |
| Keywords |
TNF
Antitumor effect
Pulmonary metastatic tumor
Lewis lung carcinoma
|
| NDC |
Medical sciences [ 490 ]
|
| Language |
eng
|
| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima University School of Medicine
|
| Date of Issued | 1987-03 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 3583799
|
