In Vitro Thermochemotherapy of Human Osteosarcoma Cells with Cis-Dichlorodiammineplatinum (II)
Hiroshima Journal of Medical Sciences Volume 35 Issue 3
Page 191-195
published_at 1986-09
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| File | |
| Title ( eng ) |
In Vitro Thermochemotherapy of Human Osteosarcoma Cells with Cis-Dichlorodiammineplatinum (II)
|
| Creator |
YAMANE Takashi
NAKABAYASHI Hidekazu
ITO Shiro
SUMII Hiroshi
KAWAI Akira
|
| Source Title |
Hiroshima Journal of Medical Sciences
|
| Volume | 35 |
| Issue | 3 |
| Start Page | 191 |
| End Page | 195 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| Abstract |
Human osteosarcoma cells (HuO-3Nl cells) and fibroblastic cells with normal human karyotype (HuO-3 cells) were derived from a patient with osteosarcoma. HuO-3N1 cells were more sensitive to heat treatment than HuO-3 cells. The combination of heat and cis-dichlorodiammineplatinum (II) (CDDP) exerted synergistic cytotoxity on HuO-3N1 cells, and was much less cytotoxic to HuO-3 cells than to HuO-3Nl cells. Therefore, thermochemotherapy with CDDP may be useful for treatment of human osteosarcoma.
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| Keywords |
Tissue culture
Thermochemotherapy
Human osteosarcoma cell
Cis-dichlorodiammineplatinum (II)
|
| NDC |
Medical sciences [ 490 ]
|
| Language |
eng
|
| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima University School of Medicine
|
| Date of Issued | 1986-09 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 3468096
|
