Assessment of Lower-limb Vascular Endothelial Function Based on Enclosed Zone Flow-mediated Dilation

Scientific Reports 8 巻 9263- 頁 2018-06-18 発行
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タイトル ( eng )
Assessment of Lower-limb Vascular Endothelial Function Based on Enclosed Zone Flow-mediated Dilation
作成者
Hirano Harutoyo
Takama Renjo
Matsumoto Ryo
Tanaka Hiroshi
Hirano Hiroki
Ukawa Teiji
Takayanagi Tsuneo
Morimoto Haruka
Nakamura Ryuji
Hashimoto Haruki
Matsui Shogo
Oda Nozomu
収録物名
Scientific Reports
8
開始ページ 9263
抄録
This paper proposes a novel non-invasive method for assessing the vascular endothelial function of lower-limb arteries based on the dilation rate of air-cuff plethysmograms measured using the oscillometric approach. The principle of evaluating vascular endothelial function involves flow-mediated dilation. In the study conducted, blood flow in the dorsal pedis artery was first monitored while lower-limb cuff pressure was applied using the proposed system. The results showed blood flow was interrupted when the level of pressure was at least 50 mmHg higher than the subject’s lower-limb systolic arterial pressure and that blood flow velocity increased after cuff release. Next, values of the proposed index, %ezFMDL, for assessing the vascular endothelial function of lower-limb arteries were determined from 327 adult subjects: 87 healthy subjects, 150 subjects at high risk of arteriosclerosis and 90 patients with cardiovascular disease (CAD). The mean values and standard deviations calculated using %ezFMDL were 30.5 ± 12.0% for the healthy subjects, 23.6 ± 12.7% for subjects at high risk of arteriosclerosis and 14.5 ± 15.4% for patients with CAD. The %ezFMDL values for the subjects at high risk of arteriosclerosis and the patients with CAD were significantly lower than those for the healthy subjects (p < 0.01). The proposed method may have potential for clinical application.
内容記述
This work was supported by JSPS KAKENHI Grant Number 16K21076.
言語
英語
資源タイプ 学術雑誌論文
出版者
Nature Research
発行日 2018-06-18
権利情報
© The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
出版タイプ Version of Record(出版社版。早期公開を含む)
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収録物識別子
[ISSN] 2045-2322
[DOI] 10.1038/s41598-018-27392-3
[DOI] https://doi.org/10.1038/s41598-018-27392-3