The Butenolide Signaling Molecules SRB1 and SRB2 Induce Lankacidin and Lankamycin Production in Streptomyces rochei
CHEMBIOCHEM 13 巻 10 号
1447-1457 頁
2012-07-09 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
The Butenolide Signaling Molecules SRB1 and SRB2 Induce Lankacidin and Lankamycin Production in Streptomyces rochei
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| タイトル ( jpn ) |
Butenolide signaling molecules, SRB1 and SRB2, that induce lankacidin and lankamycin production in Streptomyces rochei
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| 作成者 |
Tsuda Naoto
Taniguchi Akihiro
KInashi Haruyasu
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| 収録物名 |
CHEMBIOCHEM
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| 巻 | 13 |
| 号 | 10 |
| 開始ページ | 1447 |
| 終了ページ | 1457 |
| 抄録 |
Novel signaling molecule(s) that induce lankacidin and lankamycin production in Streptomyces rochei were extracted from the culture filtrate and purified by Sephadex LH20 and silica gel chromatography with the help of bioassay. Chiral HPLC and ESI-MS analyses indicated the presence of two active components, SRB1 and SRB2, and their molecular formulae were established to be C15H24O5 and C16H26O5, respectively. Based on extensive NMR analysis, SRB1 and SRB2 were determined to be 2-(1’-hydroxyl-6’-oxo-8’-methylnonyl)-3-methyl-4-hydroxybut-2-en-1,4-olide and 2-(1’-hydroxyl-6’-oxo-8’-methyldecyl)-3-methyl-4-hydroxybut-2-en-1,4-olide, respectively. These structures were finally confirmed by chemical synthesis and the absolute configuration of C-1’ was determined to be R. The synthetic 1’R-isomers induced production of lankacidin and lankamycin at around 40 nM concentration. Thus, SRB1 and SRB2 are distinct from the well-known 2,3-disubstituted γ-butyrolactone molecules such as A-factor, virginia butanolide, and SCB1 and belong to the γ-butenolide family following avenolide which has been recently isolated from Streptomyces avermitilis.
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| 著者キーワード |
natural product
antibiotics
Streptomyces
butenolides
signaling molecules
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| 内容記述 |
アクセプト後にタイトル・アブストラクト等変更あり、著者最終稿は変更前のタイトル"Butenolide signaling molecules, SRB1 and SRB2, that induce lankacidin and lankamycin production in Streptomyces rochei"
This work was supported by a Grants‐in‐Aid for Scientific Research on Innovative Areas from the Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT), and a Noda Institute for Scientific Research Grant.
Supporting information for this article is available on the WWW underhttp://dx.doi.org/10.1002/cbic.201200149.
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| 言語 |
英語
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| 資源タイプ | 学術雑誌論文 |
| 出版者 |
Wiley‐VCH Verlag
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| 発行日 | 2012-07-09 |
| 権利情報 |
Copyright © 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
This is the peer reviewed version of the following article: CHEMBIOCHEM. 2012, July 9;13(10):1447-1457, which has been published in final form at https://doi.org/10.1002/cbic.201200149. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
This is not the published version. Please cite only the published version. この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。
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| 出版タイプ | Author’s Original（十分な品質であるとして、著者から正式な査読に提出される版） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
[ISSN] 1439-4227
[ISSN] 1439-7633
[DOI] 10.1002/cbic.201200149
[PMID] 22761035
[DOI] https://doi.org/10.1002/cbic.201200149
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