Formation of β‐(1,3‐1,6)‐D‐glucan‐complexed [70]fullerene and its photodynamic activity towards macrophages

Organic and Biomolecular Chemistry Volume 15 Issue 9 Page 1990-1997 published_at 2017-03-01
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Title ( eng )
Formation of β‐(1,3‐1,6)‐D‐glucan‐complexed [70]fullerene and its photodynamic activity towards macrophages
Creator
Akiyama Motofusa
Koumoto Kazuya
Kagoshima Yuta
Li Jiawei
Suzuki Toshio
Nagasaki Takeshi
Source Title
Organic and Biomolecular Chemistry
Volume 15
Issue 9
Start Page 1990
End Page 1997
Abstract
[70]Fullerene was dissolved in water by the complexation with β‐1,3‐glucan using a mechanochemical high‐speed vibration milling apparatus. The photodynamic activity of β‐1,3 glucan‐complexed C70 was highly dependent on the expression level of dectin‐1 on the cell surfaces of macrophages. The photodynamic activity increased as a result of a synergistic effect between β‐1,3‐glucan‐complexed 1’‐acetoxychavicol acetate and the C70 complex.
Descriptions
This work was supported by JSPS KAKENHI Grant‐in‐Aid for Scientific Research (B) (Grant No. JP16H04133), Grant‐in‐Aid for Scientific Research (C) (Grant No. 26350528) and Grant‐in‐Aid for Challenging Exploratory Research (Grant No. JP16K13982).
NDC
Chemistry [ 430 ]
Language
eng
Resource Type journal article
Publisher
Royal Society of Chemistry
Date of Issued 2017-03-01
Rights
Copyright (c) 2017 The Royal Society of Chemistry
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
Publish Type Author’s Original
Access Rights open access
Source Identifier
[ISSN] 1477-0520
[DOI] 10.1039/c6ob02747d
[PMID] 28177008