Different stabilities of liposomes containing saturated and unsaturated lipids toward the addition of cyclodextrins

Organic and Biomolecular Chemistry 14 巻 22 号 5065-5072 頁 2016-06-04 発行

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タイトル ( eng )	Different stabilities of liposomes containing saturated and unsaturated lipids toward the addition of cyclodextrins
作成者	Ikeda Atsushi Funada Rikushi Sugikawa Kouta
収録物名	Organic and Biomolecular Chemistry
巻	14
号	22
開始ページ	5065
終了ページ	5072
抄録	Liposomes composed of unsaturated lipids were more stable than those containing saturated lipids toward DMe‐β‐CDx, DMe‐α‐CDx and DMe‐β‐CDx. The Hill coefficient values (n) indicated that the saturated lipid•DMe‐CDx complexes had stoichiometric ratios in the range of 1:3‒1:4, while the unsaturated lipid•DMe‐CDx complexes had ratios in the range of 1:1.5‒1:3. That is, a cis alkene group in the unsaturated lipids prevented complexation with a second DMe‐CDx in the direction toward each acyl chain. Furthermore, the liposomes composed of the unsaturated lipids were much slower to form precipitates upon the addition of α‐CDx than those of the saturated lipids. To the best of our knowledge, this is the first example showing that CDxs interact with unsaturated lipids.
内容記述	This work was supported by the Japanese Society for the Promotion of Science (JSPS) KAKENHI a Grant‐in‐Aid for Scientific Research (B) (Grant No. 25288037 and No. 16H04133) and a Grant‐in‐Aid for Challenging Exploratory Research (Grant No. 16K13982).
NDC分類	化学 [ 430 ]
言語	英語
資源タイプ	学術雑誌論文
出版者	Royal Society of Chemistry
発行日	2016-06-04
権利情報	Copyright (c) 2016 The Royal Society of Chemistry This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
出版タイプ	Author’s Original（十分な品質であるとして、著者から正式な査読に提出される版）
アクセス権	オープンアクセス
収録物識別子	[ISSN] 1477-0520 [DOI] 10.1039/c6ob00535g [PMID] 27181919