A Heterotopic Cardiac Transplantation Model for Evaluation of Rejection Using Transvenous Endomyocardial Biopsy
Hiroshima Journal of Medical Sciences Volume 39 Issue 1
Page 15-18
published_at 1990-03
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| File | |
| Title ( eng ) |
A Heterotopic Cardiac Transplantation Model for Evaluation of Rejection Using Transvenous Endomyocardial Biopsy
|
| Creator |
Matsuura Yuichiro
Matsushima Takeshi
Mukai Shogo
Kajihara Hiroki
|
| Source Title |
Hiroshima Journal of Medical Sciences
|
| Volume | 39 |
| Issue | 1 |
| Start Page | 15 |
| End Page | 18 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| Abstract |
A model of heterotopic cardiac transplantation for diagnosis of rejection is described. Heterotopic cardiac transplantations were performed in the thorax using the left innominate artery as an arterial supply with venous return into the superior vena cava. Six pairs of mongrel dogs underwent cardiac transplantation using this technique. Two dogs died postoperatively on the 2nd and 3rd day due to respiratory failure. Another four donor hearts arrested their beats in 6 to 8 postoperative days (mean 6.3 days) resulting from acute cardiac rejection. Serial echocardiographic recordings were found to be a reliable measure of acute cardiac rejection, since the left ventricular wall thickness of the donor heart increased until the donor heart stopped by rejection. Endomyocardial biopsy was easy to perform by passage of flexible cardiac biotome into the right ventricle of the donor and the recipient heart through the right internal jugular vein. Pathological findings revealed that early changes of the donor heart were interstitial edema caused by myocardial ischemia. This was followed by lymphocyte infiltration around peripheral coronary arteries and acute rejection resulting in myocyte necrosis.
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| Keywords |
Heterotopic cardiac transplantation
Acute cardiac rejection
Endomyocardial biopsy
|
| Descriptions |
This study was presented in the seventh annual meeting of Japan Cardiac Transplantation Research, May 1989.
Financial contribution was granted by Tsuchiya Memorial Medical Foundation (President Dr. Taro Tsuchiya).
|
| NDC |
Medical sciences [ 490 ]
|
| Language |
eng
|
| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima University Medical Press
|
| Date of Issued | 1990-03 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 2373638
|
