Effects of Several Volatile Anesthetics on the Ca2+-Related Functions of Skinned Skeletal Muscle Fibers from the Guinea Pig
Hiroshima Journal of Medical Sciences 40 巻 1 号
9-13 頁
1991-03 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
Effects of Several Volatile Anesthetics on the Ca2+-Related Functions of Skinned Skeletal Muscle Fibers from the Guinea Pig
|
| 作成者 |
Matsui Kazuyuki
Fujioka Yasuhiro
Kikuchi Hirosato
Yuge Osafumi
Fujii Kohyu
Morio Michio
Endo Makoto
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| 収録物名 |
Hiroshima Journal of Medical Sciences
|
| 巻 | 40 |
| 号 | 1 |
| 開始ページ | 9 |
| 終了ページ | 13 |
| 収録物識別子 |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| 抄録 |
The effects of various volatile anesthetics on intramuscular Ca2+-related functions were studied with the skinned fiber technique in guinea pig skeletal muscles. All the volatile anesthetics tested significantly enhanced Ca2+-induced Ca2+ release (CICR) from the sarcoplasmic reticulum (SR) at clinical concentrations with negligible effects both on Ca2+ sensitivity of the contractile system and on Ca2+ uptake by the SR. A comparison was made of the enhancing effect of several volatile anesthetics on CICR at clinical concentrations. Halothane was the most potent, followed by methoxyflurane, isoflurane, enflurane, sevoflurane and diethyl ether. If CICR plays an important role in triggering MH, this order of volatile anesthetics on their enhancing effect on CICR, also corresponds to their potency in triggering MH.
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| 著者キーワード |
Calcium induced calcium release (CICR)
Skinned fiber
Volatile anesthetics
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| 内容記述 |
This study was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education in Japan.
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| NDC分類 |
医学 [ 490 ]
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| 言語 |
英語
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| 資源タイプ | 紀要論文 |
| 出版者 |
Hiroshima University Medical Press
|
| 発行日 | 1991-03 |
| 出版タイプ | Version of Record（出版社版。早期公開を含む） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 1864768
|
